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Down syndrome is a set of cognitive and physical symptoms that result from having an extra chromosome 21 or an extra piece of that chromosome It is the most common. As the registry grows, families and researchers learn more about down syndrome and identify similarities and differences in the symptoms and treatment of people with down. People with down syndrome are at a greater risk for a number of health problems and conditions than are people who do not have down syndrome The symptoms of down syndrome vary from person to person, and people with down syndrome may have different problems at different times of their lives. Health care providers can check for down syndrome during pregnancy or after a child is born. Children with down syndrome, fragile x syndrome, rett syndrome, and other idds can often benefit from therapeutic speech therapy, occupational therapy, and exercises to. Children with down syndrome are at an increased risk for some health problems, but not all will have serious health problems. Down syndrome is the most frequent chromosomal cause of mild to moderate intellectual disability. Down syndrome describes a set of cognitive and physical symptoms that result from an extra copy or part of a copy of chromosome 21.