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Further, we discuss clinical experience with combination therapy and recommendations for future research using crc as an example. Method pubmed, web of science, embase, and the cochrane library were searched for. In two recent papers published in cancer cell, miao et al The cd58 copy number loss rate was 44.7% (fig 1b) Both mutations and copy number loss led to a mild decrease in mrna expression of cd58 Background immune checkpoint inhibitors have revolutionized care for a number of different cancer types Immunotherapy, especially immune checkpoint blockade (icb), holds promise as a therapeutic strategy in colorectal cancer (crc) by harnessing the patient’s immune system to target malignant cells